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It’s not clear. A 2020 JAMA study of more than 13,000 people with high heart disease risk (average age: 63) compared groups taking a common omega-3 formulation or a placebo and found no benefits to the fish oil. Other research, however — including a 2019 analysis of more than 127,000 people— showed that taking omega-3 supplements derived from fish oil reduced the risk of heart attacks and death from heart disease. Bottom line: Eat more fish and omega-3-rich foods such as nuts and seeds, and talk with your physician about an omega-3 supplement.