Is RNA hydrophobic or hydrophilic?
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Hydrophobic effects in RNA occur mainly at the level of secondary structure, making a contribution to the vertical stacking of purine and pyrimidine bases [17]. Thus, RNA necessarily requires a different strategy than protein to drive tertiary structure assembly.
Because of these charges, polar molecules like DNA or RNA can interact electrostatically with the water molecules, allowing them to easily dissolve in water. Polar molecules can, therefore, be described as hydrophilic, and non-polar molecules, which can’t easily interact with water molecules, are hydrophobic.