Avermectins (AVM) are macrocyclic lactones which have potent antihelminthic and insecticidal action. They are generally derived from the mycelia of

The avermectins are derived from a family of macrocyclic lactones produced by the soil microorganism Streptomyces avermitilis. Abamectin (avermectin B1) was introduced in 1985 as a crop insecticide against mites and some insect species.