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Rupannita
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RupannitaKnowledge Contributor
Asked: August 9, 20242024-08-09T21:09:34+05:30 2024-08-09T21:09:34+05:30In: Education

Write down Williamson synthesis with example and condition.

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Write down Williamson synthesis with example and condition.
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  1. Anjalik
    Anjalik Curator
    2024-08-09T21:14:43+05:30Added an answer on August 9, 2024 at 9:14 pm

    Williamson’s Synthesis;

    The reaction of alkyl halides with Sodium alkoxide or Sodium phenoxide to form Ether is called Williamson synthesis.
    It is a process that allows the preparation of a wide range of symmetric and asymmetric Ethers by a
    mechanism.
    In Williamson’s synthesis, the Alkyl halide is heated with alcoholic Sodium alkoxide then the Alkoxide ion is a nucleophile that displaces a Halide ion from an alkyl halide to give an ether.
    Primary Alkyl halides will give a better yield.
    This method is used for both basic and mixed Ether preparation.
    Example:
    Methyl iodide is heated with alcoholic Sodium ethoxide then the ethoxide ion acts as a nucleophile which displaces an iodide ion from an methyl iodide to give an Ethyl methyl ether

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  2. Rupannita
    Rupannita Knowledge Contributor
    2024-08-10T09:48:37+05:30Added an answer on August 10, 2024 at 9:48 am

    In Williamson’s synthesis, the Alkyl halide is heated with alcoholic Sodium alkoxide then the Alkoxide ion is a nucleophile that displaces a Halide ion from an alkyl halide to give an ether. Primary Alkyl halides will give a better yield. This method is used for both basic and mixed Ether preparation.

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