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Why does the body reject artificial organs?
Why does the body reject artificial organs?
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This is because the person’s immune system detects that the antigens on the cells of the organ are different or not “matched.” Mismatched organs, or organs that are not matched closely enough, can trigger a blood transfusion reaction or transplant rejection.
Our bodies have a defense system called the immune system, which helps protect us from foreign substances. When an artificial organ is implanted, the immune system may recognize it as foreign and try to attack or reject it.
The body may reject artificial organs due to several reasons:
Immunological response: The immune system recognizes the artificial organ as foreign and mounts an immune response, leading to inflammation and rejection. This response can occur due to the presence of non-self antigens on the surface of the artificial organ.
Material compatibility: Some materials used in artificial organs may not be biocompatible, causing irritation, inflammation, or toxic reactions in the surrounding tissues.
Infection: Artificial organs can become sites for bacterial or fungal infections, triggering an immune response and potentially leading to rejection.
Mechanical issues: Malfunction or failure of the artificial organ can stimulate an immune response or cause tissue damage, leading to rejection.
Surgical complications: Improper implantation or surgical techniques can result in tissue damage, inflammation, or infection, increasing the risk of rejection.
To mitigate rejection, researchers focus on developing biocompatible materials, improving surgical techniques, and developing immunosuppressive therapies to suppress the immune response.