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The main source of emission of Chlorofluorocarbons (CFCs) historically has been their use in refrigeration, air conditioning, and aerosol propellants. CFCs were widely used in these applications due to their stability, non-toxicity, and low reactivity with other substances. However, it was later discovered that CFCs contribute significantly to ozone depletion in the stratosphere when they break down and release chlorine atoms, which catalytically destroy ozone molecules.
Due to the Montreal Protocol and subsequent agreements, the production and use of CFCs have been largely phased out or greatly reduced worldwide. This has led to a decrease in their atmospheric concentration over time.