What are mast cells?
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Mast cells are immune cells that are derived from the myeloid lineage. These cells have pivotal role in allergic responses, inflammation, and maintaining tissue homeostasis. Mast cells originate from haematopoietic stem cells present in the bone marrow. They circulate as immature precursors within peripheral tissues before maturation. On maturation, mast cells migrate to precise locations such as skin, the respiratory tract, or gastrointestinal lining that frequently encounter environmental stimuli. On receiving any external environmental stimuli, the mast cells respond.
Mast cells act as sentinel cells of the immune system. The cell functionality includes their involvement in allergic responses. For instance, these conditions include allergic rhinitis and asthma.