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The ammonium ion (NH4+) in the body plays an important role in the maintenance of acid-base balance. The kidney uses ammonium (NH4+) in place of sodium (Na+) to combine with fixed anions in maintaining acid-base balance, especially as a homeostatic compensatory mechanism in metabolic acidosis.
It is useful to understand that in the aquatic environment NH4 is not toxic, however it does have the ability to instantly change to NH3 with a change in pH