Which of the following activity is possible by transferases?
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MraY transferase is vital for the viability of bacteria, and it is absent in eukaryotes, which makes it an attractive target for antibacterial discovery with potentially no adverse effect on humans. However, MraY, being part of the PNPT superfamily, shows structural similarities with GPT, the human paralog of MraY.8 This poses a significant challenge in developing MraY-targeted antibiotics without the risk of also targeting GPT, which can lead to cytotoxicity. Of all the known nucleoside inhibitors of MraY, tunicamycin has been reported to show promiscuity toward human GPT. It is a high-affinity competitive inhibitor for UDP-GlcNAc in human GPT