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The average lifespan of a red blood cell (RBC) in the human body is about 120 days. During this time, RBCs circulate through the bloodstream, delivering oxygen from the lungs to the tissues and organs and returning carbon dioxide to the lungs for exhalation. After approximately 120 days, they are typically removed from circulation by macrophages in the spleen, liver, and bone marrow, where they are broken down and their components are recycled.