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Multiple studies have shown that long-term calorie restriction can reduce metabolic function and slow the cellular aging process — in rats! Human trials have been limited. A 2019 study in The Lancet showed that people who reduced their calorie intake by 12 percent had lower blood pressure and cholesterol, increased insulin sensitivity and lower inflammation. The problem? The study covered only 238 people over two years, and the oldest among them were 50. Plus, calorie-restriction diets can cause muscle loss, which in turn can result in rebound weight gain and other unhealthy outcomes.