What are human hepatocytes?
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Human hepatocytes are the primary cells of the liver (accounts for approximately 60-70% of the liver cells). Hepatocytes are responsible for carrying out various essential liver functions. If the liver is thought of as the body’s processing centre, hepatocytes are the cells that do much of the actual work.
One of their most important roles is drug metabolism. Hepatocytes contain enzymes such as cytochrome P450 (CYP) enzymes that help break down medicines and other chemical compounds. This makes them particularly useful in pharmaceutical research, where scientists need to understand how a drug is metabolised, how long it may remain active, and whether it could produce potentially harmful metabolites.